Wnt10a Is a Candidate as a Non-Cellular Agent for Induction of Dental Pulp Regeneration with Dentine-Inducing Capacity.

The aim of regenerative medicine is to restore the original functions tissues and organs damaged by disease or impairment. Stem cell transfusion has been used clinically as therapy in a wide range fields. This promotes regeneration partially transfer tissue stem cells. Teeth are produced from dental germ, which induced interactions between epithelial mesenchymal Wnt signals heavily involved this process. Furthermore, it shown that β-catenin expressed nucleus odontoblasts dentinal cells located immediately under repaired dentine after pulpotomy, macrophages pulp express Wnt10a, suggesting involvement Wnt10a generation repair processes. However, little known about regenerated tissues. Hayashi et al. transplanted pulp, bone marrow, adipose cells, culture supernatants derived each them ectopic tooth transplantation. As result, we have succeeded regenerating expresses marker TRH-DE, regardless In study, model examine morphologically how change with time pulp. We then analyzed dynamics induction results study showed an increase increased these Wnt10a. Expression DSPP increases upon inhibition expression DKK1, differentiation occurs via regeneration. Therefore, candidate non-cellular agent for dentine-inducing capacity.